Naughty By Nature. De La Soul. Mobb Deep. LL Cool J. Justin Bieber. Moby. These artists - and countless others - have one thing in common: Melvin Bliss' Synthetic Substitution. Released in 1973, Bliss' Synthetic Substitution started off as a throwaway B-side to his single Reward. It would go on to become one of the most frequently sampled songs of the late 80s and early 90s, a legacy that continues to this day.